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KMID : 0385520160290040162
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Analytical Science & Technology
2016 Volume.29 No. 4 p.162 ~ p.169
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Comparative bioavailability of synthetic vitamin C and Nutra-C (calcium ascorbate) in Korean healthy volunteers
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Choi Kyung-Mi
Hoon Kim-Man
Won Hwang-Tae
Kim Jong-Dae
Park Keum-duck
Kim Mi-Young
Jung Young-Rim
Shin Hye-Seoung
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Abstract
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The purpose of this study was to compare the relative bioavailability of synthetic Vitamin C and Nutra-C® (calcium ascorbate) using a randomized parallel pharmacokinetics study design. Under fasting conditions, 20 healthy volunteers were randomly allocated to receive a single oral dose (500 mg of ascorbic acid) of either synthetic Vitamin C or Nutra-C®. Fasting blood was collected pre-dose and 1, 2, 3, 4, 7 and 10 hr post-dose. The ascorbic acid content of human serum was determined using HPLC with ultraviolet detection. The fasting serum ascorbic acid concentrations of synthetic Vitamin C and Nutra-C® were 6.734 ± 2.09 ng/mL (n = 10) and 7.542 ± 2.96 ng/mL (n = 10), respectively. The bioavailability of Nutra-C® was significantly greater (128 %, p < 0.05) than that of the synthetic Vitamin C.
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KEYWORD
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Vitamin C, Nutra-C, Bioavailability, Human serum,
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